The Complex Story of Plant Cyclic Nucleotide-Gated Channels
نویسندگان
چکیده
منابع مشابه
Cyclic Nucleotide–Gated Channels
In voltage- and cyclic nucleotide-gated ion channels, the amino-acid loop that connects the S5 and S6 transmembrane domains, is a major component of the channel pore. It determines ion selectivity and participates in gating. In the alpha subunit of cyclic nucleotide-gated channels from bovine rod, the pore loop is formed by the residues R345-S371, here called R1-S27. These 24 residues were muta...
متن کاملCyclic Nucleotide–gated Channels
abs t rac t Middendorf et al. (Middendorf, T.R., R.W. Aldrich, and D.A. Baylor. 2000. J. Gen. Physiol. 116:227– 252) showed that ultraviolet light decreases the current through cloned cyclic nucleotide–gated channels from bovine retina activated by high concentrations of cGMP. Here we probe the mechanism of the current reduction. The channels’ open probability before irradiation, P o (0), deter...
متن کاملCyclic nucleotide-gated ion channels.
Cyclic nucleotide-gated (CNG) channels are nonselective cation channels first identified in retinal photoreceptors and olfactory sensory neurons (OSNs). They are opened by the direct binding of cyclic nucleotides, cAMP and cGMP. Although their activity shows very little voltage dependence, CNG channels belong to the superfamily of voltage-gated ion channels. Like their cousins the voltage-gated...
متن کاملCa2+ permeation in cyclic nucleotide-gated channels.
Cyclic nucleotide-gated (CNG) channels conduct Na+, K+ and Ca2+ currents under the control of cGMP and cAMP. Activation of CNG channels leads to depolarization of the membrane voltage and to a concomitant increase of the cytosolic Ca2+ concentration. Several polypeptides were identified that constitute principal and modulatory subunits of CNG channels in both neurons and non-excitable cells, co...
متن کاملCooperativity in cyclic nucleotide-gated ion channels
Cooperativity is one of the marvelous "emergent" behaviors of macro-molecules undergoing multimolecular reactions (Perutz, 1990). Cooperativity sculpts the potential energy landscape of such a reaction so as to create a seemingly teleological pathway for reaching and stabilizing a particular state for example, a multimeric protein with multiple ligand sites occupied. Ligandgated ion channels pr...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2021
ISSN: 1422-0067
DOI: 10.3390/ijms22020874